His great grandfather was a respected painter, his grandmother a singer, and his father a popular songwriter. Biondi sang throughout his childhood, first performing in public at age 12 in church, and soon singing in public squares before hundreds of people. From there he competed in the Festival della Canzone Siciliana, taking third place. Biondi's musical pursuits earned him the opportunity to perform alongside such Italian vocal greats as Califano, Bongusto, and Fiorello, as well as American legend Ray Charles.

As word of his talent and skill got out, Biondi found himself collaborating with groups like the Change, Mario Brothers, and Funky Company on recordings and tours. Given his powerful and unique voice, it was not long before Biondi was encouraged to pursue a solo career. Featuring material inspired by American R&B artists like Lou Rawls, Luther Vandross, and Donny Hathaway, Biondi's debut record was released in 2006 on the boutique label Family Affair. Handful of Soul featured the single "This Is What You Are," which went immediately into heavy rotation throughout Italy and, thanks to British DJ Norman Jay, the U.K. A year later, Biondi performed the song at the Sanremo Festival in Italy, bolstering the record's popularity and helping to push it into Billboard's European Top 100 chart. Biondi's material continued to be popular; his 2009 album If was a big hit in Italy, reaching number two and selling three-times platinum.

During the 2010s, his popularity crested with his first number one album, Sun, released in 2013. Produced by Biondi along with Jean Paul Maunick of Incognito, it featured an array of big-name guests and influences: Leon Ware, Chaka Khan, Al Jarreau, and James Taylor. It charted for over a year in Italy, and when a holiday album, Mario Christmas, was released at the end of 2013, it followed Sun to the top of the charts. Biondi's seventh proper album, Beyond, was issued in 2015. ~ Evan C. Gutierrez